appendicitis

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	167
interventional	117
Observational	45
Registry	5

Studies over Time by Start Date

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Interventional Trials

Intervention Type

intervention_type	Study_Count
Procedure	43
Drug	24
Drug|Procedure	15
Other	11
Device	5
Diagnostic Test	3
Drug|Other	3
Drug|placebo	3
Other|Procedure	3
Device|Procedure	2
Behavioral	1
Device|Drug	1
Drug|Other|Procedure	1
Procedure|Radiation	1
Radiation	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	32
NA	12
Finland	9
Korea, Republic of	6
China	5
Denmark	5
Egypt	4
France	4
Turkey	4
Israel	3
Pakistan	3
Sweden	3
Croatia	2
Italy	2
Netherlands	2
Australia	1
Australia|China|Denmark|Finland|France|Germany|Greece|Hong Kong|India|Italy|Philippines|Portugal|Saudi Arabia|South Africa|Spain|Switzerland|Taiwan|Turkey|United Kingdom	1
Austria	1
Bosnia and Herzegovina	1
Brazil	1
Canada	1
Colombia	1
Czech Republic	1
Czechia	1
Hong Kong	1
Hungary|Latvia|Lithuania|Romania|Russian Federation|United States|Bulgaria|Czechia|Estonia|Georgia|Ukraine	1
Iran, Islamic Republic of	1
Ireland	1
Lithuania	1
Poland	1
Russian Federation	1
Singapore	1
Taiwan	1
Thailand	1
United Kingdom	1
United States|Argentina|Brazil|Canada|Chile|Mexico	1

Sites per Study

Site_count	Study_Count
1	94
2	10
3	2
4	1
5	1
6	1
7	1
8	1
14	1
20	1
25	1
54	1
66	1
68	1

Phase

Phase	Study_Count
N/A	77
Phase 4	18
Phase 3	11
Phase 2	9
Early Phase 1	1
Phase 2/Phase 3	1

Number of Arms

Number_of_Arms	Count_of_Studies
1	13
2	85
3	8
4	3
6	2
NA	6

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	30	2.00	13.0000	180	40.0000	40.0000
1st Qu.	30	50.00	60.0000	180	156.0000	62.7500
Median	30	116.00	100.0000	180	200.0000	200.0000
Mean	30	320.56	132.6667	180	346.4545	299.3333
3rd Qu.	30	200.00	200.0000	180	491.5000	325.5000
Max.	30	8200.00	360.0000	180	891.0000	1800.0000

Trial Group Type

group_type	Group_Count
Active Comparator	105
Experimental	91
No Intervention	20
Placebo Comparator	10
NA	6
Other	4
Sham Comparator	1

Intervention Model

intervention_model	Study_Count
Parallel Assignment	93
Single Group Assignment	18
Crossover Assignment	3
NA	3

Primary Purpose

primary_purpose	Study_Count
Treatment	84
Diagnostic	12
NA	5
Prevention	4
Supportive Care	4
Basic Science	3
Other	3
Health Services Research	1
Screening	1

Observational Studies

Studies by Country

Country	Study_Count
United States	10
NA	5
United Kingdom	5
Chile	3
Denmark	3
Korea, Republic of	3
Finland	2
Germany	2
Austria	1
Canada	1
Croatia	1
Germany|Spain	1
India|Mexico|Nigeria|Pakistan|Spain|Sudan	1
Italy	1
Netherlands	1
Singapore	1
Tunisia	1
Turkey	1
United States|Germany	1
Vietnam	1

Sites per Study

Site_count	Study_Count
1	39
5	2
7	1
9	1
29	1
37	1

Enrollment Metrics

Measure	Observational
Min	3.0
1st Qu	102.0
Median	282.0
Mean	158133.1
3rd Qu	993.0
Max	6000000.0

Observation Model

observational_model	Study_Count
Cohort	30
Case-Only	4
Case-Control	3
Case Control	3
Ecologic or Community	3
Defined Population, Natural History	1
Other	1

Time Perspective

time_perspective	Study_Count
Prospective	26
Retrospective	13
Cross-Sectional	3
NA	2
Cross-Sectional, Prospective	1

Registries

Studies by Country

Country	Study_Count
Turkey	2
Denmark	1
Ireland	1
United Kingdom	1

Sites per Study

Site_count	Study_Count
1	5

Enrollment Metrics

Measure	Registries
Min	64.0
1st Qu	95.0
Median	120.0
Mean	382.4
3rd Qu	226.0
Max	1407.0

Registry Model

observational_model	Study_Count
Cohort	4
Case-Only	1

Time Perspective

time_perspective	Study_Count
Prospective	4
Cross-Sectional	1

Follow-up

target_duration	Study_Count
30 Days	2
1 Day	1
14 Days	1
6 Months	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03324165	Comparing Proposed Algorithm and Current Practice in the Evaluation of Suspected Appendicitis	https://ClinicalTrials.gov/show/NCT03324165	Active, not recruiting	Singapore General Hospital	2018-09-30
NCT03289351	Two Different Antibiotics Versus One Antibiotic for Pediatric Perforated Appendicitis	https://ClinicalTrials.gov/show/NCT03289351	Recruiting	Phoenix Children’s Hospital	2020-12-22
NCT03248102	Finding Evidence to Treat Or Reassure in Appendicitis (FETOR)	https://ClinicalTrials.gov/show/NCT03248102	Completed	The Leeds Teaching Hospitals NHS Trust	2019-09-09
NCT03236961	Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis	https://ClinicalTrials.gov/show/NCT03236961	Recruiting	Turku University Hospital	2019-04-01
NCT04440150	Preoperative Immature Granulocyte Count and Percentage for Acute Appendisitis	https://ClinicalTrials.gov/show/NCT04440150	Completed	Kahramanmaras Sutcu Imam University	2019-06-01
NCT03186105	Feasability of Ambulatory Appendicectomy	https://ClinicalTrials.gov/show/NCT03186105	Completed	Fondation Lenval	2019-06-02
NCT03159754	Optimal Care of Complicated Appendicitis	https://ClinicalTrials.gov/show/NCT03159754	Active, not recruiting	University of Michigan	2022-06-30
NCT03106467	Practical Advantages of Single-port Over Three-port Laparoscopic Appendectomy in Children	https://ClinicalTrials.gov/show/NCT03106467	Completed	Hallym University Medical Center	2016-06-30
NCT03046758	The Safety and Pharmacokinetics of Intraperitoneal Administration in Patients Undergoing Appendectomy for Uncomplicated Appendicitis	https://ClinicalTrials.gov/show/NCT03046758	Completed	Herlev Hospital	2017-12-07
NCT03005808	Choose the Best Concentration of Ropivacaine on TAP Block for Open Appendectomy in Children	https://ClinicalTrials.gov/show/NCT03005808	Completed	Hospital Infantil Albert Sabin	2016-02-29
NCT02991937	Comparison of Medical and Surgical Treatment of Uncomplicated Acute Appendicitis in Children	https://ClinicalTrials.gov/show/NCT02991937	Recruiting	NYU Langone Health	2020-07-01
NCT02941640	Influence of the Different Ways of Appendix Stump Closure on Patient Outcome in Laparoscopic Appendectomy	https://ClinicalTrials.gov/show/NCT02941640	Completed	University Clinical Center Tuzla	2016-12-30
NCT02916134	Conservative Versus Operative ManageMent of Acute Uncomplicated Appendicitis	https://ClinicalTrials.gov/show/NCT02916134	Active, not recruiting	Beaumont Hospital	2019-08-31
NCT02881996	The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis	https://ClinicalTrials.gov/show/NCT02881996	Completed	Children’s Mercy Hospital Kansas City	2016-06-30
NCT02867072	Laparoscopic Versus Open Appendectomy	https://ClinicalTrials.gov/show/NCT02867072	Completed	University of Catania	2011-07-31
NCT02848820	Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children	https://ClinicalTrials.gov/show/NCT02848820	Recruiting	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	2020-12-31
NCT02803463	Peritoneal Closure Versus Non Closure During Open Appendectomy	https://ClinicalTrials.gov/show/NCT02803463	Completed	Bezmialem Vakif University	2016-12-31
NCT02800785	The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial	https://ClinicalTrials.gov/show/NCT02800785	Active, not recruiting	University of Washington	2020-03-05
NCT02795793	Non-operative Management for Appendicitis in Children	https://ClinicalTrials.gov/show/NCT02795793	Recruiting	Sydney Children’s Hospitals Network	2019-05-31
NCT02784704	Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections	https://ClinicalTrials.gov/show/NCT02784704	Completed	Tetraphase Pharmaceuticals, Inc.	2017-05-08
NCT02752698	Domestic Surgical Robot Clinical Study	https://ClinicalTrials.gov/show/NCT02752698	Active, not recruiting	The Third Xiangya Hospital of Central South University	2019-12-30
NCT02742402	DIAgnostic iMaging or Observation in Early Equivocal appeNDicitis	https://ClinicalTrials.gov/show/NCT02742402	Active, not recruiting	Helsinki University Central Hospital	2020-04-09
NCT02724410	Role of Intravenous Versus Home Oral Antibiotics in Perforated Appendicitis	https://ClinicalTrials.gov/show/NCT02724410	Completed	Atrium Health	2013-11-30
NCT02714023	Water And Saline Head-to-head In The Blinded Evaluation Study Trial	https://ClinicalTrials.gov/show/NCT02714023	Completed	University of Missouri-Columbia	2015-09-10
NCT02711449	Preoperative Methylprednisolone to Patients Suspected of Appendicitis Undergoing Laparoscopy	https://ClinicalTrials.gov/show/NCT02711449	Completed	Nordsjaellands Hospital	2016-09-30
NCT02664220	Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis	https://ClinicalTrials.gov/show/NCT02664220	Completed	The University of Texas Health Science Center, Houston	2018-03-31
NCT02633735	EHR-based Decision Support for Pediatric Acute Abdominal Pain in Emergency Care	https://ClinicalTrials.gov/show/NCT02633735	Active, not recruiting	HealthPartners Institute	2019-07-31
NCT02625987	Appendicectomy Skin Closure Technique: Changing Paradigms (ASC)	https://ClinicalTrials.gov/show/NCT02625987	Completed	Coordinación de Investigación en Salud, Mexico	2015-08-31
NCT02533869	The Optimization of a Low-dose Computed Tomography Protocol in Patients With Suspected Uncomplicated Acute Appendicitis	https://ClinicalTrials.gov/show/NCT02533869	Completed	Turku University Hospital	2017-06-01
NCT02483689	Evaluation of Local Anesthetic at Incision Site	https://ClinicalTrials.gov/show/NCT02483689	Recruiting	Valley Anesthesiology Consultants	2020-07-31
NCT02415335	Dexamethasone Preoperative for Patients Undergoing Laparoscopy for Suspected Appendicitis	https://ClinicalTrials.gov/show/NCT02415335	Completed	Nordsjaellands Hospital	2015-10-31
NCT02137603	Fast Track Appendectomy for Suppurative Appendicitis	https://ClinicalTrials.gov/show/NCT02137603	Completed	Johns Hopkins All Children’s Hospital	2014-12-31
NCT02110485	Randomized Controlled Trial of a Patient Activation Tool in Pediatric Appendicitis (Antibiotics Alone vs. Appendectomy)	https://ClinicalTrials.gov/show/NCT02110485	Completed	Nationwide Children’s Hospital	2017-08-31
NCT02108717	The Feasibility Study for Real-time Remote CT Reading for Suspected Acute Appendicitis Using iPhone	https://ClinicalTrials.gov/show/NCT02108717	Completed	Hanyang University	2014-05-31
NCT01283815	Laparoscopic Management of Periappendicular Abscess	https://ClinicalTrials.gov/show/NCT01283815	Completed	Helsinki University Central Hospital	2014-08-31
NCT01925014	Low vs. Standard Dose CT for Appendicitis Trial	https://ClinicalTrials.gov/show/NCT01925014	Completed	Seoul National University Bundang Hospital	2016-12-31
NCT01839435	Feasibility of Outpatient Appendectomy for Acute Appendicitis	https://ClinicalTrials.gov/show/NCT01839435	Completed	Centre Hospitalier Universitaire, Amiens	2016-02-29
NCT01825863	Ultrasound-guided Abdominal Wall Nerve Blockade in Laparoscopic Surgery for Acute Appendicitis.	https://ClinicalTrials.gov/show/NCT01825863	Completed	Bispebjerg Hospital	2013-12-31
NCT01816568	The Comparison of Single Incision Laparoscopic Appendectomy and Three Port Laparoscopic Appendectomy	https://ClinicalTrials.gov/show/NCT01816568	Completed	Maltepe University	2013-02-28
NCT01738750	Laparoscopic Versus Open Appendectomy? Let the Patient Decide	https://ClinicalTrials.gov/show/NCT01738750	Completed	University of Utah	2013-12-31
NCT01697059	Initial Antibiotics and Delayed Appendectomy for Acute Appendicitis	https://ClinicalTrials.gov/show/NCT01697059	Completed	Rhode Island Hospital	2015-05-31
NCT01678365	Safety and Efficacy of Single Daily Dose of Ceftriaxone and Metronidazole for Treatment of Complicated Appendicitis in Children	https://ClinicalTrials.gov/show/NCT01678365	Completed	HaEmek Medical Center, Israel	2009-10-31
NCT01659983	Efficacy Study of Delayed Primary Closure to Reduce Rate of Wound Infection in Complicated Appendicitis	https://ClinicalTrials.gov/show/NCT01659983	Completed	Ramathibodi Hospital	2016-03-31
NCT01572558	Conservative Treatment of Acute Appendicitis in Children	https://ClinicalTrials.gov/show/NCT01572558	Completed	Karolinska University Hospital	2012-10-31
NCT01568853	A Prospective Study of The Complement Depletion in Patients With Severe Abdominal Sepsis	https://ClinicalTrials.gov/show/NCT01568853	Completed	Jinling Hospital, China	2012-03-31
NCT01524081	Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures	https://ClinicalTrials.gov/show/NCT01524081	Completed	The Faculty Hospital Na Bulovce	2011-07-31
NCT01515293	Single Incision Versus Conventional Laparoscopic Appendectomy	https://ClinicalTrials.gov/show/NCT01515293	Completed	Hospital Universitario Virgen de la Arrixaca	2010-12-31
NCT01424631	Single Incision Versus Conventional Laparoscopic Appendectomy	https://ClinicalTrials.gov/show/NCT01424631	Completed	Mansoura University	NA
NCT01356641	Antibiotic Treatment Alone for Acute Simple Appendicitis in Children	https://ClinicalTrials.gov/show/NCT01356641	Completed	VU University of Amsterdam	2017-01-31
NCT04378868	Role of Delay and Antibiotics on Perforation Rate While Waiting Appendectomy	https://ClinicalTrials.gov/show/NCT04378868	Recruiting	Helsinki University Central Hospital	2022-12-31
NCT04281251	Endoscopic Retrograde Appendicitis Therapy	https://ClinicalTrials.gov/show/NCT04281251	Recruiting	Chinese University of Hong Kong	2021-03-31
NCT04271826	Grey Zone Appendicitis: Role of Blood Test Biomarkers to Detect Early Appendicitis and to Decrease the Incidence of Negative Appendectomy	https://ClinicalTrials.gov/show/NCT04271826	Completed	Zagazig University	2019-08-01
NCT04253899	The Management of Perforated Acute Appendicitis in Adult and Pediatric Populations	https://ClinicalTrials.gov/show/NCT04253899	Recruiting	Marshall University	2021-08-31
NCT04226482	Review of Efficacy of Used ultraSonic Energy Device	https://ClinicalTrials.gov/show/NCT04226482	Completed	University of Split, School of Medicine	2020-04-13
NCT04168866	Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon	https://ClinicalTrials.gov/show/NCT04168866	Recruiting	Yale University	2025-12-31
NCT04117061	Optimizing the Diagnosis of Acute Appendicitis	https://ClinicalTrials.gov/show/NCT04117061	Recruiting	Vilnius University	2021-01-01
NCT04083313	Analysis of Endoloops, Endostaples and Endoclips for Closing the Appendiceal Stump During Laparoscopic Appendectomy	https://ClinicalTrials.gov/show/NCT04083313	Completed	University Hospital Dubrava	2020-01-30
NCT04039750	Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis	https://ClinicalTrials.gov/show/NCT04039750	Recruiting	Prisma Health-Upstate	2021-07-31
NCT04031196	Quadratus Lumborum Block Versus Transversus Abdominis Plane Block in Children Undergoing Laparoscopic Appendicectomy	https://ClinicalTrials.gov/show/NCT04031196	Completed	Zagazig University	2019-03-01
NCT04030741	Non-operative Treatment of Acute Non-perforated Appendicitis	https://ClinicalTrials.gov/show/NCT04030741	Recruiting	King Edward Medical University	2020-12-01
NCT03985514	Acute Appendicitis: Active Observation With and Without Antibiotics	https://ClinicalTrials.gov/show/NCT03985514	Recruiting	Göteborg University	2020-05-31
NCT03947372	Comparison of Outcomes After Laparoscopic Versus Open Appendectomy in Acute Appendicitis	https://ClinicalTrials.gov/show/NCT03947372	Completed	Services Hospital, Lahore	2015-08-20
NCT03930667	Closure of the Appendix Stump in Laparoscopic Appendectomy	https://ClinicalTrials.gov/show/NCT03930667	Completed	Bozyaka Training and Research Hospital	2018-08-01
NCT03886896	Intravenous Lidocaine in Children Undergoing Laparoscopic Appendectomy	https://ClinicalTrials.gov/show/NCT03886896	Completed	Medical University of Warsaw	2020-01-15
NCT03792802	EFFECT OF USING SAME DERMATOME LÄ°NE FOR ALL PORT SÄ°TES IN LAPAROSCOPIC APPENDECTOMY IN ACUTE APANDICITIS	https://ClinicalTrials.gov/show/NCT03792802	Enrolling by invitation	Fatih Sultan Mehmet Training and Research Hospital	2019-07-01
NCT03773224	Role of Wound Irrigation After Appendectomy	https://ClinicalTrials.gov/show/NCT03773224	Completed	Mansoura University	2019-08-01
NCT03770897	Laparoscopic Appendectomy Performed by Junior SUrgeonS: Impact of 3D Visualization on Surgical Outcome	https://ClinicalTrials.gov/show/NCT03770897	Completed	Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia	2019-04-30
NCT03754777	Modified Enhanced Recovery Program in Emergency Surgery (MERES)	https://ClinicalTrials.gov/show/NCT03754777	Completed	Pirogov Russian National Research Medical University	2017-12-01
NCT03754387	Antibiotic Therapy vs Laparscopic Appendectomy in Pediatric Chronic Appendicitis	https://ClinicalTrials.gov/show/NCT03754387	Enrolling by invitation	Zunyi Medical College	2021-01-01
NCT03750032	Technical Modifications of Appendicular Stump Closure During Laparoscopic Appendectomy	https://ClinicalTrials.gov/show/NCT03750032	Recruiting	University Hospital Ostrava	2019-06-01
NCT03723642	Investigation of Oxidative Stress in Appendectomy - Open Versus Laparoscopic in Childhood and Adolescence	https://ClinicalTrials.gov/show/NCT03723642	Active, not recruiting	Medical University of Graz	2020-10-01
NCT03687502	The Role of Contrast Enhanced Ultrasound in Appendicitis	https://ClinicalTrials.gov/show/NCT03687502	Recruiting	Children’s Mercy Hospital Kansas City	2021-01-01
NCT03591419	Polymer Clips Vs Endoloop for Appendicular Stump Ligation	https://ClinicalTrials.gov/show/NCT03591419	Completed	Services Hospital, Lahore	2018-06-30
NCT03524573	(D)Elayed vs. (E)Arly (L)Aparoscopic (A)Ppendectom(Y)	https://ClinicalTrials.gov/show/NCT03524573	Recruiting	Kingston Health Sciences Centre	2020-10-31
NCT03482245	Blue Light Therapy in Reducing Inflammation During Sepsis	https://ClinicalTrials.gov/show/NCT03482245	Recruiting	University of Pittsburgh	2020-03-31
NCT03481517	Wound Infiltration With Local Anesthetic Agent for Laparoscopic Appendectomy in Adult	https://ClinicalTrials.gov/show/NCT03481517	Completed	National Taiwan University Hospital	2019-07-08
NCT03435900	Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Antibiotics for Perforated Appendicitis	https://ClinicalTrials.gov/show/NCT03435900	Completed	Herlev Hospital	2018-07-17
NCT01260064	Open Appendectomy Versus Laparoscopic Appendectomy	https://ClinicalTrials.gov/show/NCT01260064	Completed	Bakirkoy Dr. Sadi Konuk Research and Training Hospital	2011-04-30
NCT01203566	A Randomised Controlled Trial on LESS Versus Conventional Laparoscopic Appendicectomy.	https://ClinicalTrials.gov/show/NCT01203566	Completed	Chinese University of Hong Kong	2011-03-31
NCT01115153	Prophylaxis With Single Versus Five Dose of Antibiotic Therapy as Treatment of Patients With Gangrenous Acute Appendicitis	https://ClinicalTrials.gov/show/NCT01115153	Completed	Universidad Industrial de Santander	2009-11-30
NCT01096927	Non Operative Treatment for Acute Appendicitis	https://ClinicalTrials.gov/show/NCT01096927	Completed	Maggiore Bellaria Hospital, Bologna	2011-01-31
NCT01067937	Study for a Rational Management of Appendicitis in Children	https://ClinicalTrials.gov/show/NCT01067937	Completed	Nantes University Hospital	2011-04-30
NCT01024439	Transumbilical Single Incision Versus Conventional Three Incisions Laparoscopic Appendicectomy	https://ClinicalTrials.gov/show/NCT01024439	Completed	Pamela Youde Nethersole Eastern Hospital	2010-09-30
NCT01022567	Appendicectomy Versus Antibiotics in the Treatment of Acute Uncomplicated Appendicitis	https://ClinicalTrials.gov/show/NCT01022567	Active, not recruiting	Turku University Hospital	2012-06-30
NCT01007318	Safety and Efficacy Study of Single Port Laparoscopic Appendectomy in Acute Appendicitis	https://ClinicalTrials.gov/show/NCT01007318	Completed	Kyunghee University Medical Center	2010-12-31
NCT01002365	Perioperative Hyperoxygenation and Wound Site Infection Following Surgery for Acute Appendicitis	https://ClinicalTrials.gov/show/NCT01002365	Completed	Western Galilee Hospital-Nahariya	NA
NCT00981136	Single Incision Laparoscopic Surgery (SILS) Versus Laparoscopic Appendectomy	https://ClinicalTrials.gov/show/NCT00981136	Completed	Children’s Mercy Hospital Kansas City	2010-11-30
NCT00913445	Wound Healing After Emergency Appendicectomy	https://ClinicalTrials.gov/show/NCT00913445	Completed	Tampere University Hospital	2010-05-31
NCT00913380	Diagnosis of Acute Appendicitis: Low-dose Computed Tomography (CT) Versus Standard-dose CT	https://ClinicalTrials.gov/show/NCT00913380	Completed	Seoul National University Bundang Hospital	2011-04-30
NCT00908804	Open Versus Laparoscopic Appendectomy	https://ClinicalTrials.gov/show/NCT00908804	Completed	North Karelia Central Hospital	NA
NCT00854815	Irrigation Versus No Irrigation for Perforated Appendicitis	https://ClinicalTrials.gov/show/NCT00854815	Completed	Children’s Mercy Hospital Kansas City	2012-06-30
NCT02447224	Pilot Trial of Antibiotics Versus Surgery for Treating Acute Appendicitis	https://ClinicalTrials.gov/show/NCT02447224	Completed	Olive View-UCLA Education & Research Institute	2015-10-31
NCT04332809	A Randomized Controlled Trial on Wound Irrigation in Open Appendectomy.	https://ClinicalTrials.gov/show/NCT04332809	Active, not recruiting	Mansoura University	2020-03-31
NCT00806429	Transvaginal Appendectomy	https://ClinicalTrials.gov/show/NCT00806429	Completed	Yale University	2011-12-31
NCT03234296	Antibiotics vs. Placebo in Acute Uncomplicated Appendicitis	https://ClinicalTrials.gov/show/NCT03234296	Enrolling by invitation	Turku University Hospital	2019-03-30
NCT02687464	Appendectomy Versus Non-Operative Treatment For Acute Non-Perforated Appendicitis in Children	https://ClinicalTrials.gov/show/NCT02687464	Recruiting	Children’s Mercy Hospital Kansas City	2019-01-31
NCT02352519	A Comparison of UGBRS Block and Local Infiltration	https://ClinicalTrials.gov/show/NCT02352519	Completed	Baylor College of Medicine	2015-06-30
NCT00783016	Effect of Pain Control on the Diagnosis of Acute Appendicitis on the Diagnostic Accuracy of General Surgeon	https://ClinicalTrials.gov/show/NCT00783016	Completed	Seoul National University Hospital	2011-02-28
NCT00734825	Emergency Department CT Scanning for Appendicitis	https://ClinicalTrials.gov/show/NCT00734825	Completed	WellSpan Health	2008-11-30
NCT00723788	Magnetic Resonance Imaging (MRI) of Appendicitis in Children	https://ClinicalTrials.gov/show/NCT00723788	Completed	Children’s National Research Institute	2010-04-30
NCT00716703	CT Scan Using IV Contrast Alone for Pediatric Appendicitis	https://ClinicalTrials.gov/show/NCT00716703	Completed	University of Rochester	2005-10-31
NCT00616616	Single Incision Laparoscopy	https://ClinicalTrials.gov/show/NCT00616616	Completed	University of California, San Diego	2009-07-31
NCT00565682	Pain Post Abdominal Laparoscopy Prevention With Arcoxia	https://ClinicalTrials.gov/show/NCT00565682	Completed	Hospital Vozandez	NA
NCT00554008	Comparative Study of Laparoscopic Versus Open Appendectomy in Children	https://ClinicalTrials.gov/show/NCT00554008	Completed	Oregon Health and Science University	2010-12-31
NCT00552162	NOTES Transvaginal Cholecystectomy and Appendectomy	https://ClinicalTrials.gov/show/NCT00552162	Recruiting	Hadassah Medical Organization	2018-01-31
NCT00477061	Morphine Analgesia in Patients With Acute Appendicitis	https://ClinicalTrials.gov/show/NCT00477061	Completed	Tehran University of Medical Sciences	NA
NCT00469430	Study of Conservative Versus Surgical Treatment of Appendicitis	https://ClinicalTrials.gov/show/NCT00469430	Completed	Göteborg University	2007-09-30
NCT00462020	Intravenous Versus Intravenous/Oral Antibiotics for Perforated Appendicitis	https://ClinicalTrials.gov/show/NCT00462020	Completed	Children’s Mercy Hospital Kansas City	2008-11-30
NCT00435032	Early Versus Interval Appendectomy for Ruptured Appendicitis in Children	https://ClinicalTrials.gov/show/NCT00435032	Completed	University of Tennessee	2009-09-30
NCT00414375	Early Versus Delayed Operation for Perforated Appendicitis	https://ClinicalTrials.gov/show/NCT00414375	Completed	Children’s Mercy Hospital Kansas City	2009-02-28
NCT00413855	Laparoscopic Appendectomy for Chronic Right Lower Abdominal Pain	https://ClinicalTrials.gov/show/NCT00413855	Completed	Maxima Medical Center	NA
NCT00323453	Wound Infection Alexis Wound Retractor	https://ClinicalTrials.gov/show/NCT00323453	Completed	Santa Barbara Cottage Hospital	2008-06-30
NCT00230971	Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI)	https://ClinicalTrials.gov/show/NCT00230971	Completed	Wyeth is now a wholly owned subsidiary of Pfizer	2008-09-30
NCT00229060	Doripenem in the Treatment of Complicated Intra-Abdominal Infections	https://ClinicalTrials.gov/show/NCT00229060	Completed	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	NA
NCT00210938	Doripenem in the Treatment of Complicated Intra-Abdominal Infections	https://ClinicalTrials.gov/show/NCT00210938	Completed	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	NA
NCT00195351	Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection	https://ClinicalTrials.gov/show/NCT00195351	Completed	Wyeth is now a wholly owned subsidiary of Pfizer	2008-02-29
NCT00135603	Antibiotic Therapy Versus Appendectomy for Acute Appendicitis	https://ClinicalTrials.gov/show/NCT00135603	Completed	Assistance Publique - Hôpitaux de Paris	2008-02-29

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03080103	Appendectomy Versus Conservative Treatment for Uncomplicated Acute Appendicitis	https://ClinicalTrials.gov/show/NCT03080103	Completed	Associazione Chirurghi Ospedalieri Italiani	2018-06-30
NCT02831556	Point of Care 3D Ultrasound for Various Applications: A Pilot Study	https://ClinicalTrials.gov/show/NCT02831556	Recruiting	Duke University	2025-01-31
NCT02731924	Point of Care Ultrasound for Evaluation of Suspected Appendicitis in the Emergency Department	https://ClinicalTrials.gov/show/NCT02731924	Recruiting	WellSpan Health	2020-12-31
NCT02730585	Diagnostic Performance of C Reactive Protein and Delta CRP in Acute Appendicitis	https://ClinicalTrials.gov/show/NCT02730585	Completed	University of Monastir	2013-12-31
NCT02679547	The Effect of Breastfeeding on the Development of Appendicitis in Adults	https://ClinicalTrials.gov/show/NCT02679547	Enrolling by invitation	Sisli Hamidiye Etfal Training and Research Hospital	2019-12-31
NCT02673528	Laparoscopic Assisted or Total Laparoscopic Appendectomy	https://ClinicalTrials.gov/show/NCT02673528	Completed	Medical Park Gaziantep Hospital	2015-08-31
NCT02556983	CT Dose Simulation Study for Appendicitis	https://ClinicalTrials.gov/show/NCT02556983	Completed	Seoul National University Bundang Hospital	2017-02-28
NCT02507674	Point of Care 3D Ultrasound for Pediatric Appendicitis: a Pilot Study	https://ClinicalTrials.gov/show/NCT02507674	Completed	Duke University	2016-06-16
NCT02311452	Comparative Effectiveness of Intravenous v. Oral Antibiotic Therapy for Serious Bacterial Infections	https://ClinicalTrials.gov/show/NCT02311452	Completed	Children’s Hospital of Philadelphia	2012-12-31
NCT02271932	Multi-institutional Trial of Non-operative Management of Appendicitis	https://ClinicalTrials.gov/show/NCT02271932	Active, not recruiting	Nationwide Children’s Hospital	2019-11-01
NCT02047786	A Comparison of Appendicectomy Outcomes in Children Between Paediatric and General Surgical Centres in Scotland	https://ClinicalTrials.gov/show/NCT02047786	Completed	University of Edinburgh	2010-12-31
NCT02018016	The Hospital Volume Relationship in Appendicectomy Outcomes	https://ClinicalTrials.gov/show/NCT02018016	Completed	University of Edinburgh	2010-12-31
NCT02017951	Geographic Influences on Appendicectomy Outcomes	https://ClinicalTrials.gov/show/NCT02017951	Completed	University of Edinburgh	2010-12-31
NCT01967745	Laparoscopic Versus Open Appendectomy	https://ClinicalTrials.gov/show/NCT01967745	Completed	Varazdin General Hospital	2009-12-31
NCT01830387	Comparative Study of Polymetric Clips (Hem-o-Lok) Versus Historical Endoscopic Staplers for Laparoscopic Appendectomy	https://ClinicalTrials.gov/show/NCT01830387	Completed	Duke University	2014-09-30
NCT01734837	TICAP - Titanium Clips for Appendiceal Stump Closure	https://ClinicalTrials.gov/show/NCT01734837	Completed	Aesculap AG	2013-07-31
NCT01718275	Non-operative Management of Early Appendicitis in Children	https://ClinicalTrials.gov/show/NCT01718275	Active, not recruiting	Nationwide Children’s Hospital	2014-02-28
NCT01718171	Inflammatory Response in Appendicitis	https://ClinicalTrials.gov/show/NCT01718171	Completed	Cirujanos la Serena	2012-01-31
NCT01698099	Diagnostic Accuracy of Serum Bilirubin in the Prediction of Perforated Appendicitis	https://ClinicalTrials.gov/show/NCT01698099	Completed	University Hospital Tuebingen	2011-08-31
NCT03349814	Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies	https://ClinicalTrials.gov/show/NCT03349814	Completed	Herlev Hospital	2019-05-15
NCT01652170	The Performance of the APPY1 Test in the Evaluation of Possible Acute Appendicitis	https://ClinicalTrials.gov/show/NCT01652170	Completed	Venaxis, Inc.	2014-02-28
NCT01376466	Impact of CT on Diagnosis of Acute Appendicitis	https://ClinicalTrials.gov/show/NCT01376466	Completed	University of Aarhus	2011-02-28
NCT01348464	A Trial on Laparoscopic Appendectomy Versus Single Port Appendectomy	https://ClinicalTrials.gov/show/NCT01348464	Completed	Gachon University Gil Medical Center	NA
NCT04407117	Appendicitis During the National Lockdown During the COVID-19 Pandemic	https://ClinicalTrials.gov/show/NCT04407117	Completed	Nordsjaellands Hospital	2020-04-19
NCT04214340	Appendicitis in Adults and Children in France-A Prospective Study by the French Surgical Association Multicenter Cohort	https://ClinicalTrials.gov/show/NCT04214340	Completed	Association Francaise de Chirurgie	2016-06-30
NCT04207645	Modification and Validation of the RIPASA Score for Diagnosis of Acute Appendicitis	https://ClinicalTrials.gov/show/NCT04207645	Recruiting	Soba University Hospital	2020-07-31
NCT04163211	Abdominal Drainage During Appendicectomy - Resources Down the Drain: A Retrospective Cohort Study	https://ClinicalTrials.gov/show/NCT04163211	Completed	The Whittington Hospital NHS Trust	2018-11-01
NCT04033211	NOVOsyn® for Trocar Incision After Laparoscopic Appendectomy and Cholecystectomy	https://ClinicalTrials.gov/show/NCT04033211	Recruiting	Aesculap AG	2020-10-31
NCT03902262	Acute Abdomen in Kawasaki Disease	https://ClinicalTrials.gov/show/NCT03902262	Completed	National Institute of Pediatrics, Mexico	2019-02-15
NCT03776435	CT Carcinogenic Risk in Patients With Appendicitis	https://ClinicalTrials.gov/show/NCT03776435	Recruiting	Seoul National University Bundang Hospital	2020-12-15
NCT03504878	Cost-effectiveness Analysis and Case-based Payment Norm Modeling on Appendicitis Patients at Hanoi Medical University Hospital	https://ClinicalTrials.gov/show/NCT03504878	Completed	Hanoi Medical University	2016-12-31
NCT03450642	Complement Diagnosis of Acute Appendicitis	https://ClinicalTrials.gov/show/NCT03450642	Completed	University of Exeter	2014-10-31
NCT03414853	Free Text Prediction Algorithm for Appendicitis	https://ClinicalTrials.gov/show/NCT03414853	Active, not recruiting	National University Hospital, Singapore	2019-07-01
NCT01192620	Pediatric Appendicitis Pathway Study	https://ClinicalTrials.gov/show/NCT01192620	Completed	Oregon Health and Science University	2011-08-31
NCT01054417	APPEndicitis and Laparoscopic Criteria; APPEL Study	https://ClinicalTrials.gov/show/NCT01054417	Completed	University Medical Center Groningen	2011-04-30
NCT00925145	Single Incision Laparoscopic Appendectomy in the Community Utilizing Conventional Instruments	https://ClinicalTrials.gov/show/NCT00925145	Completed	University of British Columbia	2010-10-31
NCT00888888	Colonic Resections in Patients With Suspected Appendicitis	https://ClinicalTrials.gov/show/NCT00888888	Completed	Cirujanos la Serena	2010-06-30
NCT04142203	Implementation of 23 Hour Surgery Model in a Tertiary Hospital	https://ClinicalTrials.gov/show/NCT04142203	Active, not recruiting	Kuopio University Hospital	2020-05-30
NCT02580487	Perioperative Pain Management of Pediatric Appendectomy Patients	https://ClinicalTrials.gov/show/NCT02580487	Completed	Kuopio University Hospital	2015-09-30
NCT03119740	Postoperative Complications After Appendectomy	https://ClinicalTrials.gov/show/NCT03119740	Completed	Ludwig Boltzmann Institute for Operative Laparoscopy	2016-10-30
NCT00677417	Diagnostic Value of Hyperbilirubinaemia as a Predictive Factor for Appendiceal Perforation in Acute Appendicitis	https://ClinicalTrials.gov/show/NCT00677417	Completed	Ruhr University of Bochum	2008-05-31
NCT00630071	Diagnostic Value of Procalcitonin in Patients With Acute Appendicitis	https://ClinicalTrials.gov/show/NCT00630071	Completed	Ruhr University of Bochum	NA
NCT00530998	Minimally Invasive Surgery: Using Natural Orfices	https://ClinicalTrials.gov/show/NCT00530998	Completed	University of California, San Diego	2019-09-30
NCT00528138	Hyperbilirubinemia in Acute Appendicitis as a Predictor of Perforation	https://ClinicalTrials.gov/show/NCT00528138	Completed	Cirujanos la Serena	2008-09-30
NCT00195923	Prospective Randomized Evaluation of Antibiotic Regimen Following Appendectomy for Perforated Appendicitis	https://ClinicalTrials.gov/show/NCT00195923	Completed	Children’s Mercy Hospital Kansas City	NA

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03185637	Children’s Surgery in Sub-Saharan Africa	https://ClinicalTrials.gov/show/NCT03185637	Completed	King’s College London	2017-05-31
NCT02304653	Acute Appendicitis: The Influence of C-reactive Protein and Leucocytes on Clinical Decision-making	https://ClinicalTrials.gov/show/NCT02304653	Completed	Odense University Hospital	2013-11-30
NCT03988660	The Circulating Fibrocyte - a Novel and Accurate Biomarker in Diagnosing Acute Appendicitis in Adults	https://ClinicalTrials.gov/show/NCT03988660	Completed	University Hospital of Limerick	2019-04-14
NCT03791229	Pain and Discomfort After Appendectomy in Children	https://ClinicalTrials.gov/show/NCT03791229	Enrolling by invitation	Sakarya University	2019-03-31
NCT04462588	Immature Granulocyte [IG] Count and Percentage for Medical Treatment of Uncomplicated Acute Appendicitis	https://ClinicalTrials.gov/show/NCT04462588	Completed	Kahramanmaras Sutcu Imam University	2020-06-01